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Panjin production base has own R&D laboratory , pilot-scale and scale-up production, and can complete the development and process optimization of new products in a short time. The main types of organic synthesis that the company is good at are: Grignard reaction, bromination reaction, catalytic hydrogenation reaction, phase transfer catalytic reaction, etc.

1. Grignard reaction and organolithium reaction to prepare aldehydes, ketones, acids, boric acid

Product：3,5-Bis(trifluoromethyl)acetophenone, 3,5-Bis(trifluoromethyl)benzaldehyde, 2-(trifluoromethyl)acetophenone, 2-(trifluoromethyl)benzaldehyde，3,5-difluorobenzaldehyde, 3,5-difluoroacetophenone, 3,4-difluorobenzaldehyde,

 

2.Halogenation reaction

（1）bromination or chlorination of Aromatic compounds ：

Product：3,5-Bis(trifluoromethyl)bromobenzene

 

（2）Alpha bromination of ketones：

Product：2-bromo-3’,5’-Diacetoxyacetopheone, 2-bromo-4’-(trifluoromethyl)acetophenone，3-bromo-1,1,1-trifluoroacetone, 1,1-dibromo-3,3,3-trifluoroacetone

 

(3) Conversion of heterocyclic hydroxyl groups to chlorine

Product：4-chloropyrrolopyrimidine, 2,4-dichloropyrrolopyrimidine

 

（4）Diazotization, bromination：

Product：4-bromopyridine hydrochloride，2-chloro-5-bromotrifluoromethylbezene

 

3.Hydrogenation reaction：

(1) Reduction of cyano group to amino group: Product: 3,5-Bis(trifluoromethyl)ebnzyl amine

(2) Hydrogenated double bond: 4,4-dimethylcyclohexanone

(3) Nitro reduction: 4-fluoro-2-methoxy-5-nitroaniline

(4) Dechlorination: Flavonolate

 

4.Oxidation reaction

(1) Double bond oxidation to cis-diol: Sofosbuvir intermediate, unylinker

(2) Oxidation of acetophenone to benzoic acid

(3) TEMPO oxidation to produce aldehydes and ketones

 

5.Chloromethylation:

Product:2-chloro-5-trifluoromethylbenzol, 2,4-difluorobenzamide

 

6.Heterocycle preparation:

(1) Indoles: 5-cyanoindole, 7-fluoroindole, 2-methyl-5-fluoroindole, 5-bromoindole, 5-nitroindole, 7-cyanoindole Morpholine

(2) Pyrimidines: Fimasartan intermediate, tofacitib intermediate

(3) Benzofurans: vilazodone intermediate, amiodarone hydrochloride intermediate

(4) Flavonoids: acacetin